Chloride channels in the sarcoplasmic reticulum of muscle
نویسندگان
چکیده
منابع مشابه
Cardiac sarcoplasmic reticulum chloride channels regulated by protein kinase A.
In heart cells, several plasma membrane ion channels are targets for phosphorylation. However, it is not known whether sarcoplasmic reticulum (SR) ion channels, which are also essential in the regulation of cardiac function, are regulated by second-messenger systems. Here, we show that a Cl- channel in the cardiac SR membrane is activated by the catalytic subunit of protein kinase A (PKA). Puri...
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Dr. Edwards and colleagues have demonstrated that many types of vertebrate and invertebrate muscle possess an extensive representation of the endoplasmic reticulum, and have observed that this may be arranged in longitudinal members running parallel to the myofibrils, and in transverse membranes, often located at the level of the junctions of A and I bands. Dr. Porter has called attention to so...
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TRPV1 represents a non-selective cation channel activated by capsaicin, acidosis and high temperature. In the central nervous system where TRPV1 is highly expressed, its physiological role in nociception is clearly identified. In skeletal muscle, TRPV1 appears implicated in energy metabolism and exercise endurance. However, how as a Ca(2+) channel, it contributes to intracellular calcium concen...
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The sarcoplasmic reticulum (SR) of smooth muscles presents many intriguing facets and questions concerning its roles, especially as these change with development, disease, and modulation of physiological activity. The SR's function was originally perceived to be synthetic and then that of a Ca store for the contractile proteins, acting as a Ca amplification mechanism as it does in striated musc...
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ژورنال
عنوان ژورنال: Progress in Biophysics and Molecular Biology
سال: 1997
ISSN: 0079-6107
DOI: 10.1016/s0079-6107(97)00029-1